References

Asthma and Lung UK. Press release: Lung conditions kill more people in the UK than anywhere in Western Europe. 2022. https://www.asthmaandlung.org.uk/media/press-releases/lung-conditions-kill-more-people-uk-anywhere-western-europe (accessed 20/01/2025)

Asthma and Lung UK. Your child's asthma review. 2024. https://www.asthmaandlung.org.uk/conditions/asthma/child/manage/review (accessed 22/01/2025)

Asthma and Lung UK. Asthma and your child. https://www.asthmaandlung.org.uk/conditions/asthma/child (accessed 22/01/2025)

BTS, NICE, SIGN. Algorithm E; pharmacological management of asthma in children under 5. 2024. https://www.nice.org.uk/guidance/ng245/resources/algorithm-e-pharmacological-management-of-asthma-in-children-under-5-bts-nice-sign-pdf-13556516369 (accessed 20/01/2025)

BTS, NICE, SIGN. Asthma: diagnosis, monitoring and chronic asthma management. NICE guideline [NG245]. 2024. https://www.nice.org.uk/guidance/NG245 (accessed 20/01/2025)

GINA. Global Strategy for Asthma Management and Prevention – 2024 update. 2024. https://ginasthma.org/wp-content/uploads/2024/05/GINA-2024-Strategy-Report-24_05_22_WMS.pdf (accessed 21/01/2025)

Primary Care Respiratory Update. Primary Care Respiratory Society. 2024. https://www.pcrs-uk.org/pcru/autumnwinter-2024 (accessed 20/01/2025)

MHRA. Montelukast: reminder of the risk of neuropsychiatric reactions. 2024. https://www.gov.uk/drug-safety-update/montelukast-reminder-of-the-risk-of-neuropsychiatric-reactions (accessed 22/01/2025)

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SIGN. Alternative diagnoses in wheezy children. [SIGN 244]. 2019. https://rightdecisions.scot.nhs.uk/asthma-pathway-bts-nice-sign-sign-244/diagnosis/alternative-diagnoses-in-wheezy-children/ (accessed 20/01/2025)

Clinical guidelines for the care of children aged under 5 with asthma: An overview of the recent national guidelines

02 February 2025
Volume 36 · Issue 2

Abstract

Heather Henry explains why it is critical that nurses in primary and community health services understand what has been described as a ‘sea change’ in the national guidelines for managing asthma

This is the first of 3 articles providing an in-depth overview of the recently updated British Thoracic Society (BTS), Scottish Intercollegiate Guidelines Network (SIGN), and National Institute for Health and Care Excellence (NICE) guidelines for the care of people with asthma, published on 27 November 2024. This article aims to equip nurses with the knowledge and tools needed to deliver evidence-based care and improve outcomes for children with asthma aged under 5 years.

Asthma is the most common long-term condition amongst children and young people and is one of the top ten reasons for emergency hospital admission in the UK (Royal College of Paediatrics and Child Health, 2020). Asthma and Lung UK reported (2022) that the UK has the worst death rate for lung conditions such as asthma and chronic obstructive pulmonary disease (COPD) than anywhere else in western Europe. Given how common is, and how poorly the UK compares, it is critical that nurses in primary and community services understand what has been described as a ‘sea change’ in national guidelines (Hickman, 2024; BTS/SIGN/NICE, 2024).

What's changed?

These new guidelines resolve longstanding differences between the previous BTS and SIGN guidelines, and NICE guidelines. In addition, health professionals describe the new guidelines as an opportunity for an ‘upgrade’ people's inhalers (PCRS, 2025). For example, for older children and adults, this might mean a move (where clinically indicated) towards maintenance and reliever therapy (MART) regimes, enabling people to receive controller medication alongside a long acting reliever with every dose, thus reducing the reliance on short acting bronchodilators (SABA), which can be associated with poor control and increased exacerbations (GINA, 2024). Diagnostic testing has also changed in those aged 5 and over, with a move towards blood eosinophils or fractional exhaled nitric oxide (FeNO) as the first line. The following paragraph and algorithm references refer to the 2024 BTS/SIGN/NICE guidelines.

Particular challenges in children under 5 years

Asthma is characterized by airway inflammation, hyper-responsiveness, and variable airflow obstruction. Symptoms include wheezing, coughing, breathlessness, and chest tightness. Unfortunately, very young children commonly experience these symptoms for several reasons, often due to viral infections that can resolve themselves. In addition, the gold standard for asthma care is objective testing such as FeNO, which small children cannot do.

The committee that drew up the new guidelines explain that young children with recurrent wheeze and features suggesting asthma should be treated empirically with a low dose of inhaled corticosteroid (ICS) for 8 to 12 weeks and then stopped. If symptoms soon re-appear after stopping ICS, this suggests that the ICS was beneficial rather than the improvement being due to the natural remission of a viral episode (figure 1). The committee agreed that once the presence of asthma is established with reasonable certainty regular paediatric low-dose ICS should be restarted, with subsequent steps added if needed (paragraph 1.9.6; figure 1). This means that nurses need to be able to explain these trials of treatment, which can be stopped and restarted, to worried parents.

Figure 1. (Source: Algorithm E; pharmacological management of asthma in children under 5)

As diagnosis in this age group is so difficult, the committee agreed that thresholds for referral to an asthma specialist should be low (paragraph 1.9.6,).

Care of a small child with breathing problems can be an emotional situation. A full explanation of why a small child may need regular inhaled steroids, especially as they may not appear to carers to ‘work’ immediately (compared to beta agonists) and addresses concerns about the effect on the child's growth.

Initial clinical assessment (paragraph 1.1)

  • Cough, polyphonic wheeze, breathlessness, noisy breathing
  • Diurnal or seasonal variation
  • Triggers
  • Family history of asthma
  • Symptoms suggestive or alternative diagnosis (SIGN 158, 2019)
  • Be aware that even if a clinical examination is normal, the child may still have asthma.

    Diagnosis (paragraphs 1.2 and 1.3)

  • If asthma is suspected and the child is unable to complete objective tests, code for suspected asthma and review the child on a regular basis (see figure 1)
  • If they still have symptoms by the age of 5, attempt objective tests.
  • If a child is unable to perform objective tests by the age of 5, try doing the tests again every 6 to 12 months (FeNO, bronchodilator reversibility with spirometry, peak expiratory flow with variability or skin prick test; total immunoglobulin and blood eosinophils). These tests will be covered fully in the next article in this series.
  • If there is still doubt about the diagnosis, refer to a paediatric specialist for a second opinion.
  • Refer to a specialist if the child has had an emergency admission, or two or more admissions to an emergency department within the last 12 months.
  • Treatment (Figure 1)

  • Remember that asthma is essentially an inflammatory disease requiring controller medications, usually inhaled corticosteroids, so monotherapy with a SABA is never recommended.
  • The main treatment in this age group is regular doses of inhaled corticosteroids, via metered dose inhaler, via a valve holding chamber, plus a SABA.
  • Consider adding on a leukotriene receptor antagonists (LTRA). Be aware of the neuropsychiatric side effects of an LTRA (Medicines and Healthcare products Regulatory Agency - MHRA, 2024)
  • If a paediatric moderate dose of ICS as maintenance therapy and a trial of an LTRA has been unsuccessful or not tolerated, stop the LTRA and refer the child to a specialist in asthma care.
  • Self-management (paragraph 1.1)

  • Prepare a personalised asthma action plan (PAAP) for carers
  • Discuss triggers and their avoidance, especially indoor and outdoor air pollution, such as passive smoking
  • Offer self-management education for carers by signposting carers to the Asthma and Lung UK website (nd) or other reliable resources.
  • Annual review (Asthma and Lung UK, 2024)

    At annual review check for:

  • symptom control (children aged 4 and over should have a valid and reliable asthma control questionnaire such as Qoltech (nd)
  • time off school or preschool due to asthma
  • any exacerbations, especially those requiring oral steroids, admissions to emergency department or in-patient admissions
  • triggers and their management
  • good inhaler technique
  • regular use of ICS and frequency of SABA use – being aware of over-use of SABA
  • whether child is now old enough for objective testing and update the PAAP accordingly.
  • Shared decision-making

    Decisions about treatment and care are best when they are made alongside children and their parents or carers. Healthcare professionals should involve children and young people in decisions about their healthcare in ways that are appropriate to their maturity and understanding (NICE, 2021). Some children and young people will be able to give informed consent themselves, some will be able to contribute to the discussion, and others may not be able to be involved at all. Nurses should give clear information, discuss options and listen carefully to the family's views and concerns.

    Ask about:

  • What they are most worried about
  • How treatment will affect day to day life
  • Whether there are changes that can be made to help control asthma, such as helping carers to stop smoking or identify/manage triggers
  • Safety-netting - advise on when and how to contact a healthcare professional if they are worried about anything